Yes. You understood correctly from the picture. Today we are talking about Amphetamine (alpha-methylphenethylamine). Today, this is the best nootropic invented by mankind. Modafinil, Methylphenidrate will also appear as junior colleagues (mainly via links), and Grandpa Cocaine will slip through. Where can we go without it when it comes to improving brain activity and stimulants.
Best nootropics
Immediately it is necessary to make a reservation that in Russia, they are all prohibited. Some are on pain of death - prisons. Therefore, for all sorts of supervisory authorities, I will remind you that all the facts presented here have a scientific basis and evidence. Links available.
For those who are in a tank - well, or in a liquor store - Amphetamine is a psychostimulant used to treat Attention Deficit Hyperactivity Disorder (ADHD, including in children from 6 years old), Narcolepsy (sudden falling asleep), obesity, and some others.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3353150/
The above medicinal properties of drugs of the amphetamine group, of course, deserve respect, but do not limit their other use.
Everyone is delighted with the ability of the substance and its derivatives to stimulate the Central Nervous System (CNS). A surge of energy, mental and physical recovery, increased self-confidence and turning off internal fears. A forgotten joy of life and a light euphoric touch of good mood appear. Add to that appetite suppression and the ability to go without sleep, and here is the NRT pill from the "Realm of Darkness" in your hands.
Promotional video:
You have to understand that I'm talking about the drug-nootropic substance Amphetamine, which we practically do not have. What is sold on the streets under this name in the overwhelming percentage of cases is just a variation on the well-known formula. There, of course, there are some effects of the original, but in connection with the artisanal manufacture of chemically not very useful precursors, it is not a fact that the advantages of using such a powder for the brain will defeat the toxic load on the rest of the body.
On the other hand, a huge number of its buyers today do not have a brain at all. He only includes legs and a hard dance for the whole night.
Good or evil? States, doctors or stimulant? Which one is who?
The drug is often accused of being addictive. Allegedly, you can become addicted to him. Can. Our reward system in the brain is designed so that you can become addicted to anything and then fall ill with withdrawal syndrome. Sweets, TV, House 2, any hobby are addiction options.
Interestingly, the prohibition of amphetamine in Russia began with the arrival of the capitalists. In 1996 it was still being produced and sold, and in 1998 it was added with a separate note and was strictly withdrawn. I wonder why? On the capitalist Russian, did he act differently? Or interfered with the pricing of cocaine, which, just in those years, began to cheerfully supply to our region?
Surprisingly, a similar story with Amphetamine and in the west. Except for prohibiting it, of course.
After World War II, it was sold freely (without a prescription) everywhere and by the seventies, it began to seriously press coke on all fronts. The action is similar. Euphoria, only less. Lists of psychoactive substances subject to regulation were urgently adopted. Dragged into the UN. Banned from use without a prescription. Cocaine business, up the hill again
Then, just still ADHD, no one had. It is not clear to whom to prescribe, if for fun, read: "to suppress depressive states" - it is impossible.
Now with this disease everyone is in complete order. Increases from year to year. Amphetamine is being eaten in kilograms again. And, you won't believe it! Again the cocaine is upset - sales are falling. All over the world sighs begin. Wai wai wai! What a misfortune, the generation of drug addicts is growing! Apparently, they will soon be repressed again.
I wonder where are all those who ate amphetamines in the post-war thirty years? If you believe the horror stories, these people should be without exception in the graves with heart attacks. The rest, curl like ivy along the walls of the houses of sorrow. But in real life, it turns out, there was a baby boom. It's strange.
Here, instead of a link to a scientific work, I will give a link to On Reddit. There, the practicing doctor answers the questions of the sufferers. For general development, very useful. And in principle it is interesting.
www.reddit.com/r/adderall/comments/60ddg1/i_am_a_medical_doctor_and_i_am_here_to_answer/
Now, let's talk about the good
Magnetic resonance imaging studies have shown that long-term use of amphetamines reduces the number of structural and functional disorders commonly seen in ADHD patients and improves the functioning of various parts of the brain, such as the right caudate nucleus of the basal ganglion.
citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.688.837&rep=rep1&type=pdf
Studies of the clinical use of stimulants have shown that long-term use of amphetamines for ADHD is safe and effective
www.ncbi.nlm.nih.gov/pmc/articles/PMC2769923/
A nine-month randomized controlled trial of children with ADHD was reviewed, which showed an average increase in IQ of 4.5, as well as long-term improvement in attention and a decrease in episodes of destructive behavior and hyperactivity.
Current models of ADHD suggest that the disorder is associated with functional impairments in neurotransmitter systems in the brain; namely, with impaired dopamine neurotransmission in the mesocorticolimbic projection and neurotransmission of norepinephrine in the macula macula and prefrontal cortex. Approximately 80% of patients using stimulants experience improvements in ADHD symptoms.
jamanetwork.com/journals/jamapsychiatry/fullarticle/1485446
Children with ADHD on stimulant drugs tend to be more friendly with peers and family members, do better in school, are less distracted and do less rash, and have better concentration.
journals.plos.org/plosone/article?id=10.1371/journal.pone.0116407
I have no ADHD! Everything is lost?
AND NOW ATTENTION !!! EVERYTHING STIMULANTS TREAT FOR ADHD, WELL HELPS IN ADAPTATION TO LIFE AND THE ORDINARY PERSON!
Therapeutic doses of amphetamine produce marked improvements in mental performance, including in working memory functioning, episodic memory, and inhibitory control in healthy adults. Confidence, sociability, concentration, vigilance, goal-achieving behavior.
www.ncbi.nlm.nih.gov/pmc/articles/PMC43771 …
The nootropic effects of amphetamine are associated with the indirect activation of the dopamine D1 receptor and the A2 adrenergic receptor in the prefrontal cortex. Therapeutic doses of amphetamine also improve the efficiency of the cerebral cortex, which in turn is associated with improvements in working memory in all individuals
/dx.doi.org/10.1007/s00213-010-1853-4
Stimulants increase cognitive function, physical strength, endurance and performance, while decreasing reaction times.
pharmrev.aspetjournals.org/content/66/1/193
Scientists and stimulants. Personal relationships
Scientists are conducting an amusing discussion - how ethical it is to urge oneself on the exam with stimulants while the slow-witted from the neighboring desks scratch their turnips. It seems that they are inclined that the norms. It didn't get lost.
The famous journal Nature conducted a survey among scientists and immediately found out that one in five uses stimulants in everyday life. Those who are still cautious (67%) admitted that they would very much like to take them, but they stop prescription and ambiguous side effects.
Some knowledge of human nature suggests that if more than 20% openly stated that they use stimulants to improve brain function, and 67% evasively whispered that they would like to, then they accept everything. Perhaps, except for the remaining 13%. I'm talking about scientists now.
Anyone who panics about psychostimulants is answered by doctors with a different point of view. They prove that psychostimulants in childhood even help the formation of personality.
link.springer.com/article/10.1023%2FA%3A10… A Very Childish Moral Panic: Ritalin
Improving the functions of the brain, human communication and other well-known benefits of psychostimulants is called a new trend (trend) of modern science
www.sciencedirect.com/science/article/pii/S…
After the scientists, surgeons also pulled up. They also turned out to be lovers of psychostimulants. Systemic, so to speak. In order not to get up twice, the surgeons admitted that cocaine is respected too.
bmcmedicine.biomedcentral.com/articles/10…
Unsurprisingly, research (double-blind, as expected) has shown impressive effects of stimulants on chess players. The results have improved significantly.
www.europeanneuropsychopharmacology.com/art..30019-6/abstract
It seems that apart from the notorious increased potential for abuse, stimulants have nothing special to show. Even, heart function is not affected in healthy people.
healthland.time.com/2011/12/12/adhd-drugs-d…
Everyone forgot about neurotoxicity when it turned out that neurons grow over time. Sometimes even a better version of yourself.
It is clear that all this is true, with adequate use, without "marathons" and exorbitant doses. But this is the case with all drugs. Paracetamol, for example, is much more toxic. Frequent use allows you to forget about a cold, against the background of a fallen off liver.
It is sad that up to a third of those convicted in Russia for drugs are imprisoned for amphetamine. It is unlikely, of course, they used it to enhance the cognitive functions of the brain, but being a fool is not a criminal offense. Try not to get caught. And yes! This was not propaganda, but advice.
