Scientists at the University of Notre Dame at South Bend (USA) have found that the protein enzyme RIPK1, which is involved in cell necrosis, is able to block the growth of malignant tumors and the occurrence of metastases. The researchers hope to use this compound to treat highly dangerous forms of cancer. This was announced in a press release on MedicalXpress.
Researchers have shown that RIPK1 helps reduce the number of mitochondria, the organelles that provide energy for metabolism, in cells. This, in turn, leads to the development of oxidative stress, when a large number of reactive oxygen species arise, which damage proteins, lipids and DNA.
Under such conditions, cells begin to self-destruct during apoptosis or controlled cell death, which is one of the lines of defense against tumors.
Cell death can be induced when the epithelial cells lining the inner surfaces of organs and body cavities are detached from their “scaffolding” network of intercellular proteins. Although this process prevents metastasis, tumors can develop resistance to it. According to the researchers, RIPK1 will help solve this problem.
Necrosis is a pathological form of cell death, when a cell is destroyed as a result of infection or heat and other types of physical impact, and its contents are poured into the intercellular space. During apoptosis, cell death occurs according to the genetic program, and its remains are effectively removed from the tissue without causing inflammation.
