Scientists at the Dana-Farber Cancer Research Institute (USA) have identified molecular targets in malignant cells of two aggressive and almost unresponsive forms of cancer. This was announced in a press release on MedicalXpress.
Synovial sarcoma is a rare type of soft tissue (synovium) cancer that is usually diagnosed in young people. Rhabdoid tumors occur in children under two years of age, affecting the brain, kidneys, and other organs.
The researchers found that the development of synovial sarcoma and rhabdoid tumors is due to the ncBAF chromatin-remodeling complex, which is involved in the regulation of the activity of a number of genes. It plays an important role in the packaging of chromatin, a chromosome substance made up of DNA, RNA and proteins.
It was shown that ncBAF contains BRD9 and GLTSCR1, unique subunits that are not found in other similar complexes. Their inhibition with the help of special compounds disrupts the proliferation (division) of malignant cells and inhibits the development of tumors. Scientists hope the study results will help develop new treatments for synovial sarcoma and rhabdoid tumors.