A team of researchers from Singapore has been able to combine several drugs to create an anti-aging cocktail. They tested the combination on the nematodes Caenorhabditis elegans, worms that are a favorite subject of laboratory research.
The authors from the National University of Singapore (National University of Singapore) showed that the combination they found slowed down the aging process and extended the life of nematodes in half.
Despite the fact that nematodes differ significantly in their structure from humans, the study of aging processes and the effect on these processes in worms is useful - many mechanisms are found in further study in humans.
It is important that already existing drugs that are used in medical practice were used to compose the “rejuvenating cocktail”. These include rapamycin, prescribed to patients after organ transplantation, rifampicin, metformin, psora-4, and allantoin. Pairwise combinations of some of these drugs really made it possible to significantly prolong the life of nematodes.
The researchers explain that this is the largest drug-related life extension ever achieved for adults. The authors note that the mixture of drugs not only prolonged life, but also did not harm health, including reproductive health.
