In the United States alone, nearly 50 million Americans suffer from some degree of allergy. The causes of allergies are not well understood: they can range from sunlight to common onions, but the most common cause of allergies is pollen from flowering plants. Symptoms are just as varied - a runny nose, cough, sore throat, pain in the eyes or itching on the body - then each allergy sufferer can continue this list according to their symptoms.
Allergies are not easy to cure: at first, in order to identify the body's allergic reaction to a specific allergen, the patient has to undergo a series of scarification tests. The doctor makes several scratches on the skin of the hand and applies solutions of the suspected allergens to them. After two or three days, a reaction to individual allergens appears in the form of skin redness, then the procedure is repeated, and only then, after identifying all possible allergens, can the actual treatment begin.
Allergy treatment is carried out by methods of immunotherapy: the doctor injections weekly injects the patient with small concentrations of mixtures of identified allergens. The concentrations of the mixtures, like the doses, are gradually increased, thus literally teaching the patient's immune system to properly respond to their effects. The treatment is long, takes from three to five years, but it is impossible not to be treated - allergies are sometimes deadly in their extremely severe forms of manifestation in the form of asthmatic suffocation, anaphylactic shock or Quincke's edema. Moreover, it is advisable to start treatment as early as possible, even in childhood. The response to such treatment in children is not difficult to predict.
In any case, this treatment is FDA approved, as are the extracts, serums and dosages of allergens used.
In Europe, another, newer, method of immunotherapy is used, in which the patient takes allergens in the form of desensitizing serum sublingually, that is, under the tongue, waiting for their absorption, and then spitting out the solution. This method of treatment is good at least because it is more gentle, besides, allergens are delivered in close proximity to immunomodulatory cells, which are present in high concentrations in the oral mucosa.
But this method is also not sinless: ingestion of any of the allergenic compounds, which occurs very easily, can irritate the cells of the esophagus, causing acid reflux (the throwing of the acidic contents of the stomach into the esophagus). This happens especially often with children.
The solution to all these allergy treatment problems was found by William Reisaker, M. D. of Cornell University. His invented method of delivering desensitizing serum to the oral cavity using a special toothpaste containing the allergens necessary for immunotherapy in variable concentrations can revolutionize the process of treating allergies, reducing it to several weeks. To do this, you just need to brush your teeth daily with Allerdent paste, which is supplied in two tubes by the New York biopharmaceutical company Allovate, created by Reisaker.
Despite the convenience for the patient, the method is difficult to implement in the United States because the FDA has not included it on the approved list. Therefore, insurance companies do not pay for treatment with the Reisaker method. In addition, American allergists are clearly not eager to switch to it - 150-250 sessions of injections on the patient's healed soul provide them with financial well-being. Namely, a specific list of identified allergens for a given patient depends on the attending allergist.
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Although the path to the masses is a thorny one, Dr. Reisaker is confident that oral allergy therapy through the oral mucosa will soon be on the tip of the tongue in the literal sense of the word. It is not for nothing that he is now busy developing a paste that fights peanut allergies, which is very important for the United States due to the prevalence of products based on it.
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