Scientists at Case Western Reserve University have identified the molecular mechanism that determines the lifespan of worms and mammals. It turned out that animals with high levels of certain proteins in their bodies live longer and suffer less age-related diseases. The researchers' article was published in the journal Nature Communications. The press release is available on the EurekAlert website!
Experts have found that increasing or decreasing the concentration of proteins called Kruppel-like transcription factors (KLFs) can prolong or shorten the life of the round nematode Caenorhabditis elegans. These compounds regulate the activity of genes by suppressing their expression, a process where information in DNA is used to synthesize biopolymers. KLF is found not only in worms, but also in mammals, including humans.
With age, the KLF level decreases. Considering that these proteins are important for maintaining the function of blood vessels, their loss provokes the development of hypertension, cardiovascular disease and even dementia. Kruppel-like transcription factors control autophagy - the destruction of defective cells, their organelles and by-products by the body itself. Otherwise, there is an accumulation of cellular "debris" and toxic substances, which shortens life.