The processes of memory and recollection formation are still one of the most poorly studied areas of human physiology. And while the mechanisms of the formation of new memories can still be influenced in some way, the processes of “forgetting” are not so easy to control. But recently, an American scientist from the Perelman School of Medicine at the University of Pennsylvania, in a series of experiments, discovered an enzyme responsible for the long-term storage of memories. Impact on him can literally "deprive him of memory."
In the process of forming memories, an important role is played by a structure called the synapse - the site where two neurons connect. As we found out from a series of laboratory studies, the formation of memories requires the expression of certain genes, which is controlled by the ACSS2 enzyme. During the formation of a memory, the synapse is rebuilt under the influence of this enzyme. The study showed that the ACSS2 enzyme affects genes associated with memory, and also regulates the creation of new synaptic connections.
In the course of laboratory experiments on mice, it was found that a decrease in the concentration of ACSS2 contributed to the "shutdown" of the memory processes. The rodents were divided into 2 groups: each group was shown a ball and offered to play with it. In the first group, the level of ACSS2 was normal, in the second, this enzyme was absent. The next day, mice with a normal enzyme content did not show interest in the ball, as they saw it the day before, but those with a low ACSS2 level were interested in the toy as well as the first time. Experts emphasize that in case of a successful outcome of a series of tests, such an approach can become very popular in medical practice. For example, for patients with post-traumatic stress disorder who find it difficult to get rid of obsessive memories of traumatic events.
VLADIMIR KUZNETSOV
